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Alpha-Lipoic Acid: Therapeutic Potential in Diabetic Neuropathies

Author

Listed:
  • Victoria Serhiyenko

    (Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine)

  • Ludmila Serhiyenko

    (Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine)

  • Mychailo Krasnyi

    (Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine)

  • Alexandr Serhiyenko

    (Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine)

Abstract

Diabetic neuropathy due to nerve damage caused by uncontrolled hyperglycemia is a common and serious complication strongly associated with diabetes mellitus. Its management focuses on long-term durable glycaemic control, multifactorial cardiovascular risk intervention, pathogenesis-oriented therapy. Clinical trials clearly suggest beneficial effects of α-lipoic acid (ALA) consumption on lipid metabolism profile, endothelial activation, its anti-inflammatory, antithrombotic and antiatherosclerotic properties. We reviewed available evidence of the benefits of ALA administration, especially to patients with diabetic neuropathy, diabetic peripheral neuropathy, diabetic cardiovascular autonomic neuropathy, including effects on glucose and lipids metabolism parameters, thrombocyte aggregation state, endothelial function and antioxidant/anti-inflammation properties.

Suggested Citation

  • Victoria Serhiyenko & Ludmila Serhiyenko & Mychailo Krasnyi & Alexandr Serhiyenko, 2018. "Alpha-Lipoic Acid: Therapeutic Potential in Diabetic Neuropathies," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(3), pages 57-61, May.
    • Handle: RePEc:adp:jcrdoj:v:7:y:2018:i:3:p:57-61
    DOI: 10.19080/CRDOJ.2018.07.555713
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    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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