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Insulin Resistance in Type 1 Diabetes: Evidence and New Insights

Author

Listed:
  • Paola Irma Guidone

    (Department of Paediatrics, University of Chieti, Italy)

  • Paola Di Filippo

    (Department of Paediatrics, University of Chieti, Italy)

  • Stefano Tumini

    (Department of Paediatrics, University of Chieti, Italy
    Center of Pediatric Diabetology, University of Chieti, Italy)

Abstract

Although the main etiopathogenic mechanism of Type 1 Diabetes Mellitus is autoimmunity, over the past decade it has been shown that Insulin Resistance also plays a key role in the pathogenesis and in the development of micro- and macrovascular complications , defininig a condition termed as “double diabetes†. Double diabetes has increased with the raised trend of obesity and it could explain the increased risk of cardiovascular complications in Type 1 Diabetes Mellitus subjects compared to the general population, even in condition of good glycaemic control. There are some tools that allow to use clinical parameters to quantify Insulin Resistance but especially the beneficial effect of complications prevention measures. Recently it has been shown that the management of the metabolic syndrome components can also be effective in reducing the cardiovascular risk in patients with Type 1 Diabetes since the pediatric age.

Suggested Citation

  • Paola Irma Guidone & Paola Di Filippo & Stefano Tumini, 2018. "Insulin Resistance in Type 1 Diabetes: Evidence and New Insights," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 36-39, March.
    • Handle: RePEc:adp:jcrdoj:v:6:y:2018:i:3:p:36-39
    DOI: 10.19080/CRDOJ.2018.06.555686
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    1. Paola Irma Guidone & Paola Di Filippo & Stefano Tumini, 2018. "Insulin Resistance in Type 1 Diabetes: Evidence and New Insights," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 1-4, March.
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    1. Paola Irma Guidone & Paola Di Filippo & Stefano Tumini, 2018. "Insulin Resistance in Type 1 Diabetes: Evidence and New Insights," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 1-4, March.

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      Keywords

      juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
      All these keywords.

      JEL classification:

      • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
      • Z0 - Other Special Topics - - General

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