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Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice

Author

Listed:
  • Luis F Hernandez

    (Diabetes Research Institute, University of Miami Miller School of Medicine, USA)

  • Peter Buchwald

    (Diabetes Research Institute, University of Miami Miller School of Medicine, USA
    Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, USA)

  • Midhat H Abdulreda

    (Diabetes Research Institute, University of Miami Miller School of Medicine, USA
    Department of Surgery, University of Miami Miller School of Medicine, USA)

Abstract

Metabolism of the amino acid L-arginine is implicated in many physiological and pathophysiological processes including autoimmune conditions such as type 1 diabetes (T1D). Alternate arginine metabolism through the citrulline-nitric oxide (NO) or the ornithine pathways can lead to proinflammatory or immune regulatory effects, respectively. In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nω-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice.

Suggested Citation

  • Luis F Hernandez & Peter Buchwald & Midhat H Abdulreda, 2018. "Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(3), pages 49-55, January.
    • Handle: RePEc:adp:jcrdoj:v:5:y:2018:i:3:p:49-55
    DOI: 10.19080/CRDOJ.2018.05.555661
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    1. Luis F Hernandez & Peter Buchwald & Midhat H Abdulreda, 2018. "Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(3), pages 1-7, January.
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    1. Luis F Hernandez & Peter Buchwald & Midhat H Abdulreda, 2018. "Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(3), pages 1-7, January.

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      Keywords

      juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
      All these keywords.

      JEL classification:

      • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
      • Z0 - Other Special Topics - - General

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