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Cannabinoids Receptors in Liver: Diet and Physiopathology

Author

Listed:
  • Valeska Castillo

    (Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile)

  • Cynthia Barrera

    (Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile)

  • Rodrigo Troncoso

    (Laboratorio de Enfermedades Crónicas Asociadas a la Nutrición, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile)

  • Ana María Ronco

    (Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile)

  • Miguel Llanos

    (Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile)

Abstract

The Endocannabinoid system (SEC), located in the central nervous system and several peripheral tissues, is an important modulator of many metabolic functions. This system, is composed by cannabinoid receptors type 1 and 2 (CB1R; CB2R), their endogenous ligands, known as Endocannabinoids, and the enzymes involved in their synthesis and degradation. It has been suggested that a hyperactivated SEC originates metabolic disruptions in several tissues, resulting in typical manifestations of the metabolic syndrome. Liver steatosis due to consumption of a high fat diet is a pathophysiological condition associated to a perturbed SEC. In this condition, it has been shown an increased expression of CB1R and/or higher endocannabinoid levels in hepatic cells, which may exert an autocrine/paracrine stimulation of CB1R and CB2R.

Suggested Citation

  • Valeska Castillo & Cynthia Barrera & Rodrigo Troncoso & Ana María Ronco & Miguel Llanos, 2017. "Cannabinoids Receptors in Liver: Diet and Physiopathology," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 4(1), pages 11-14, September.
    • Handle: RePEc:adp:jcrdoj:v:4:y:2017:i:1:p:11-14
    DOI: 10.19080/CRDOJ.2017.04.555628
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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