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Bariatric Surgery for the Treatment of Diabetic Kidney Disease

Author

Listed:
  • William P Martin

    (Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, Ireland)

  • Neil G Docherty

    (Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, Ireland
    Department of Gastrosurgical Research and Education, University of Gothenburg, Sweden)

  • Carel W Le Roux

    (Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, IrelandAuthor-Workplace-Name: Department of Gastrosurgical Research and Education, University of Gothenburg, Sweden
    Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, Ireland
    Investigative Science, Imperial College London, UK)

Abstract

Diabetic kidney disease is increasing in prevalence concordant with the inter-related diabetes and obesity pandemics. The potential mechanisms by which bariatric surgery may improve the course of diabetic kidney disease need to be understood to determine potential usefulness and risks of these interventions. Renal haemodynamics are altered in patients with diabetes and obesity and glomerular hyperfiltration is implicated as an initiating event in the genesis of renal functional decline. Effacement of glomerular podocyte foot processes and consequent albuminuria occur adaptively in response to glomerular hypertension, and when compounded by metabolic deregulation in the form of insulin resistance, hyperglycemia, and dyslipidaemia precipitate renal inflammation and oxidative stress.

Suggested Citation

  • William P Martin & Neil G Docherty & Carel W Le Roux, 2017. "Bariatric Surgery for the Treatment of Diabetic Kidney Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 3(5), pages 90-93, August.
    • Handle: RePEc:adp:jcrdoj:v:3:y:2017:i:5:p:90-93
    DOI: 10.19080/CRDOJ.2017.03.555624
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    References listed on IDEAS

    as
    1. Nathan R Hill & Samuel T Fatoba & Jason L Oke & Jennifer A Hirst & Christopher A O’Callaghan & Daniel S Lasserson & F D Richard Hobbs, 2016. "Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-18, July.
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    More about this item

    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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