IDEAS home Printed from https://ideas.repec.org/a/adp/jcrdoj/v12y2019i2p23-31.html
   My bibliography  Save this article

Exploring the Mechanism of Insulin Action, Differential Insulin Sensitivity and Insulin Resistance

Author

Listed:
  • Vinod Nikhra

    (Department of Medicine, NDMC Medical College, India)

Abstract

Correlating Altered Insulin Sensitivity and MetS: Insulin is an anabolic hormone and regulates glucose homeostasis and other metabolic processes in various organs. With aging, there occurs an impairment of glucose-stimulated insulin pulse mass, amplitude and rhythmicity due to deterioration of β-cell function and progressive loss of β-cell mass. Further, with aging there occurs a reduction in insulin sensitivity leading to insulin resistance (IR) involving liver, striated muscle, adipose tissue and other organs. At the cellular level, the insulin triggers signaling cascades that regulate cell metabolism, cell proliferation and cell survival.

Suggested Citation

  • Vinod Nikhra, 2019. "Exploring the Mechanism of Insulin Action, Differential Insulin Sensitivity and Insulin Resistance," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 12(2), pages 23-31, October.
    • Handle: RePEc:adp:jcrdoj:v:12:y:2019:i:2:p:23-31
    DOI: 10.19080/CRDOJ.2019.11.555831
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/crdoj/pdf/CRDOJ.MS.ID.555831.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/crdoj/CRDOJ.MS.ID.555831.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/CRDOJ.2019.11.555831?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Dominic J. Withers & Julio Sanchez Gutierrez & Heather Towery & Deborah J. Burks & Jian-Ming Ren & Stephen Previs & Yitao Zhang & Dolores Bernal & Sebastian Pons & Gerald I. Shulman & Susan Bonner-Wei, 1998. "Disruption of IRS-2 causes type 2 diabetes in mice," Nature, Nature, vol. 391(6670), pages 900-904, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yue Hu & Min Zhou & Kai Zhang & Xiangquan Kong & Xiaoyan Hu & Kang Li & Li Liu, 2014. "Lack of Association between Insulin Receptor Substrate2 rs1805097 Polymorphism and the Risk of Colorectal and Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    2. Preetam Guha Ray & Debasis Maity & Jinbo Huang & Henryk Zulewski & Martin Fussenegger, 2023. "A versatile bioelectronic interface programmed for hormone sensing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Xiaoyun Lei & Shi Huang, 2017. "Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-13, November.

    More about this item

    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jcrdoj:v:12:y:2019:i:2:p:23-31. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.