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In Vitro Preparation of H2O2 Inactivated Rabies Vaccine and Related Immunogenicity

Author

Listed:
  • Kareem Essam

    (Faculty of biotechnology, October university of Modern Science and Arts, Egypt)

  • Reham Mohsen

    (Faculty of biotechnology, October university of Modern Science and Arts, Egypt)

  • Eman Amin Ismail

    (The International Center for Advanced Researchers (ICTAR-Egypt), Egypt)

  • Aly Fahmy Mohamed

    (The Holding Company for production of vaccines a, sera and drugs (VACSERA), Egypt)

Abstract

The aim of the present work is to produce local H2O2 inactivated vaccine and monitor its quality to the currently available in the Egyptian market. Data revealed that H2O2 could inactivate rabies virus within 3 hrs. Produced vaccine potency was evaluated using mice inoculation assay indicating that the ED50 of test vaccine was >2.5 IU according to the WHO regulation.

Suggested Citation

  • Kareem Essam & Reham Mohsen & Eman Amin Ismail & Aly Fahmy Mohamed, 2018. "In Vitro Preparation of H2O2 Inactivated Rabies Vaccine and Related Immunogenicity," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 3(4), pages 69-76, August.
    • Handle: RePEc:adp:ijoprs:v:3:y:2018:i:4:p:69-76
    DOI: 10.19080/IJOPRS.2018.03.555619
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