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Tenofovir Alafenamide versus Tenofovir Disoproxil Fumarate: Systematic Review and Meta-Analysis

Author

Listed:
  • Jacques Lukenze Tamuzi

    (Community Health Division, Stellenbosch University, South Africa)

  • Jonathan Lukusa Tshimwanga

    (Division of Family medicine, Stellenbosch University, South Africa)

  • Andre Nyandwe Hamama Bulabula

    (Division of infectious diseases, Stellenbosch University, South Africa)

  • Ley Muyaya Muyaya

    (Division of infectious diseases, Stellenbosch University, South Africa)

Abstract

Background: Highly active antiretroviral therapy (HAART) has greatly reduced morbidity and mortality. Despite the impact of antiretroviral therapy (ART), mortality in successfully treated HIV infected patients remains higher than in the general uninfected population, more specifically in Sub-Saharan Africa. In fact, ART has demonstrated toxicity. tenofovir disoproxil (TDF) is widely known, even so, TDF is known as nephrotoxic. Recently, tenofovir alafenamide (TAF) was found.

Suggested Citation

  • Jacques Lukenze Tamuzi & Jonathan Lukusa Tshimwanga & Andre Nyandwe Hamama Bulabula & Ley Muyaya Muyaya, 2018. "Tenofovir Alafenamide versus Tenofovir Disoproxil Fumarate: Systematic Review and Meta-Analysis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 2(5), pages 123-138, March.
    • Handle: RePEc:adp:ijoprs:v:2:y:2018:i:5:p:123-138
    DOI: 10.19080/IJOPRS.2018.02.555600
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    1. Jacques Lukenze Tamuzi & Jonathan Lukusa Tshimwanga & Andre Nyandwe Hamama Bulabula & Ley Muyaya Muyaya, 2018. "Tenofovir Alafenamide versus Tenofovir Disoproxil Fumarate: Systematic Review and Meta-Analysis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 2(5), pages 1-16, March.
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    1. Jacques Lukenze Tamuzi & Jonathan Lukusa Tshimwanga & Andre Nyandwe Hamama Bulabula & Ley Muyaya Muyaya, 2018. "Tenofovir Alafenamide versus Tenofovir Disoproxil Fumarate: Systematic Review and Meta-Analysis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 2(5), pages 1-16, March.

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