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Impact of Heat Shock Proteins in Hepatocellular Carcinoma

Author

Listed:
  • Mihir Y Parmar

    (Bharat Institute of Technology, Jawaharlal Nehru Technological University, India)

  • Sachin Kumar Sharma
  • Dinesh Pore

    (Parul Institute of Pharmacy and Research, Parul University, India)

Abstract

Heat shock proteins are highly conserved proteins, expressed at low levels under normal conditions. Heat shock proteins significantly induced in response to cellular stresses and lead to heat shock response, which could help cancer cells to adapt to stress conditions. As molecular chaperones, Heat shock proteins play critical roles in protein homeostasis, apoptosis, invasion and cellular signaling transduction. A heat shock protein over expression is widely reported in many human cancers due to constant stress condition in tumor microenvironment. Heat shock proteins often associated with poor prognosis in many types of human cancers. Up regulation of Heat shock proteins may serve as diagnostic and prognostic markers in hepatocellular carcinoma

Suggested Citation

  • Mihir Y Parmar & Sachin Kumar Sharma & Dinesh Pore, 2018. "Impact of Heat Shock Proteins in Hepatocellular Carcinoma," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(3), pages 64-66, December.
    • Handle: RePEc:adp:ijcsmb:v:5:y:2018:i:3:p:64-66
    DOI: 10.19080/IJCSMB.2018.04.555663
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