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Evaluation of antioxidant and cytotoxic properties of Vernonia amygdalina

Author

Listed:
  • Omede A
  • Suleiman MS
  • Atanu FO
  • Momoh S
  • Friday ET

    (Department of Biochemistry, Kogi State University, Nigeria)

  • Sheneni VD
  • Jegede ER

    (Department of Medical Biochemistry, Kogi State University, Nigeria)

Abstract

The present investigation was carried out to evaluate the antioxidant activity and cytotoxic properties of Vernonia amygdalina. The free radical scavenging activity using a stable radical; 2, 2-Diphenyl-1-picryl hydrazyl, lipid peroxidation assay (DPPH), and nitric oxide inhibitory assay gave the highest percentage inhibition as 74.55±1.07%; IC50 = 1.831, 60.42±0.11; IC50 = 3.84 ± 1.03 and 71.26±0.48; IC50 = 0.99mg/ml, respectively. This is comparable to the standards quercetin used (P>0.05). In addition; total phenol, total flavoniods, anthocyanin and proanthocyanidine of the extract were determined using established methods. The results obtained justify the scavenging activity of the extracts. Furthermore, the extracts possessed very low cytotoxicity to brine-shrimp lethality test, when compared with the reference standard (Potassium dichromate, LC50 = 0.003±μg/mL).

Suggested Citation

  • Omede A & Suleiman MS & Atanu FO & Momoh S & Friday ET & Sheneni VD & Jegede ER, 2018. "Evaluation of antioxidant and cytotoxic properties of Vernonia amygdalina," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 4(4), pages 81-86, May.
    • Handle: RePEc:adp:ijcsmb:v:4:y:2018:i:4:p:81-86
    DOI: 10.19080/IJCSMB.2018.03.555644
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