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Epigenetics- The Science beyond Genetics

Author

Listed:
  • Atmakuri Shanmukha Ramya
  • Sumit Majumdar
  • Mahesh Babu T
  • Baratam Srinivas
  • Kameswara Rao A
  • Naga Himabindu V

    (Accredited Parliamentary Assistant, Belgium)

Abstract

Epigenetics code the information determining gene expression that is often not directly encoded in the DNA. The molecular basis of epigenetic memory remains a subject of intense debate, which is likely to arise from the collaboration of several mechanisms, including histone modifications, transcription factors and DNA methylation. Amongst all, DNA methylation is one of the key epigenetic factors involved in regulation of gene expression and genomic stability, and is biologically necessary for the maintenance of many cellular functions. This review presents the basic principles behind these epigenetic pathways and highlights the evidence suggesting that their mis-regulation which can culminate in cancer.

Suggested Citation

  • Atmakuri Shanmukha Ramya & Sumit Majumdar & Mahesh Babu T & Baratam Srinivas & Kameswara Rao A & Naga Himabindu V, 2018. "Epigenetics- The Science beyond Genetics," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 4(3), pages 51-54, April.
    • Handle: RePEc:adp:ijcsmb:v:4:y:2018:i:3:p:51-54
    DOI: 10.19080/IJCSMB.2018.03.555638
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