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MicroRNA: A Major Key in Pain Neurobiology

Author

Listed:
  • Unda
  • Santiago R
  • Villegas
  • Emilce A

    (Instituto de Biotecnología, Centro de Investigación e Innovación Tecnológica, Universidad Nacional de La Rioja, Argentina)

Abstract

MiRNAs are single-stranded small noncoding RNAs that consist of approximately 22 nucleotides, that are involve in a wide range of biological processes including pain physiopathology. Because of their role as master switches in regulation and signaling pathways through modifications in nociceptive receptors, ion channels, pro-inflammatory molecules, emotional and cognitional behaviors associated with pain, the triggered enthusiasm for miRNAs as promising therapeutic targets is still active. Furthermore, the expression of specific miRNA can be helpful to predict treatment response in patients which suffer pain conditions that are poorly controlled by the currently available analgesics. This evidence is supported in several researches with animal pain models that we briefly review in this article to approximate in the understand of the role and neurobiology process through miRNA represents a major key for future therapeutics in pain, emphasizing in the neuropathic pain condition.

Suggested Citation

  • Unda & Santiago R & Villegas & Emilce A, 2017. "MicroRNA: A Major Key in Pain Neurobiology," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 3(5), pages 73-79, December.
    • Handle: RePEc:adp:ijcsmb:v:3:y:2017:i:5:p:73-79
    DOI: 10.19080/IJCSMB.2017.03.555621
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