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A Study of the Effects of Medium Choice on Infected-Cell Viability and Survival in Transportation- Analysis of a Covid Model, HCoV-OC43-infected MRC-5 Cell and Cellfree HCoV-OC43, for Viability During Transportation

Author

Listed:
  • Michael PD Fishwick
  • Sebastien Farnaud

    (Centre for Discoveries in Life Sciences, Coventry University, Coventry, UK)

  • Mark C Turner

    (Institute for Cardio-Metabolic Medicine, University Hospital Coventry and Warwickshire (UHCW), Coventry, Warwickshire, UK)

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 highlighted major challenges related to sample storage and transportation, which contributed to high rates of false-negative diagnostic results. Toward the later stages of the pandemic, lysis buffers were introduced to reduce these false negatives; however, their use compromised host cell integrity, potentially affecting viral analysis when viral loads are low. These limitations raised concerns regarding both host cell viability and viral stability during sample transport.

Suggested Citation

  • Michael PD Fishwick & Sebastien Farnaud & Mark C Turner, 2026. "A Study of the Effects of Medium Choice on Infected-Cell Viability and Survival in Transportation- Analysis of a Covid Model, HCoV-OC43-infected MRC-5 Cell and Cellfree HCoV-OC43, for Viability During Transportation," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 65(3), pages 57768-57774, May.
    • Handle: RePEc:abf:journl:v:65:y:2026:i:3:p:57768-57774
    DOI: 10.26717/BJSTR.2026.65.010205
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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