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Dissolution Profile of Oniria Plus®, A Nutraceutical Containing Melatonin and Valerenic Acid Formulated In Prolonged-Release Caplets

Author

Listed:
  • Patricia García Rodríguez
  • Sara Serrano

    (Research and Development Department, ITF Research Pharma, S.L.U., Alcobendas, Spain)

  • Javier González García
  • Ana Doyle Sánchez

    (Medical Department, ITF Research Pharma, S.L.U., Alcobendas, Spain)

Abstract

Oniria Plus® is a nutraceutical formulated as prolonged release caplets (film-coated tablets designed specifically with a capsule shape for easy swallowing), containing 1.98 mg of melatonin and 4 mg of valerenic acid, intended to support physiological sleep. In vitro tests show its controlled dual dissolution profile: an initial release of both actives of about 40% in the first 30 minutes, followed by a sustained release of the remaining 60% over 300 minutes, indicating its potential effectiveness for promoting and maintaining sleep.

Suggested Citation

  • Patricia García Rodríguez & Sara Serrano & Javier González García & Ana Doyle Sánchez, 2025. "Dissolution Profile of Oniria Plus®, A Nutraceutical Containing Melatonin and Valerenic Acid Formulated In Prolonged-Release Caplets," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 61(2), pages 53589-53593, April.
    • Handle: RePEc:abf:journl:v:61:y:2025:i:2:p:53589-53593
    DOI: 10.26717/BJSTR.2025.61.009593
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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