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Endoplasmic Reticulum Stress-Dependent Sensitivity of EGFR, ERBB2, TOB1, and CEBPB Gene Expressions to Glutamine Deprivation in U87MG Glioblastoma Cells

Author

Listed:
  • Oleksandr H Minchenko
  • Yulia M Viletska
  • Serhiy V Danilovskyi
  • Artem O Tykhomyrov
  • Denys V Kolybo

    (Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Ukraine)

Abstract

Glutamine is a necessary substrate for glioblastoma cells and is important for tumor growth. We studied the impact of ERN1 knockdown on EGFR, ERBB2, TOB1, and CEBPB gene expressions in U87MG glioblastoma cells in response to glutamine deficiency. It was shown that the expression level of EGFR and ERBB2 genes was resistant to glutamine deprivation in control glioblastoma cells but ERN1 knockdown lead to up-regulation these gene expressions.

Suggested Citation

  • Oleksandr H Minchenko & Yulia M Viletska & Serhiy V Danilovskyi & Artem O Tykhomyrov & Denys V Kolybo, 2025. "Endoplasmic Reticulum Stress-Dependent Sensitivity of EGFR, ERBB2, TOB1, and CEBPB Gene Expressions to Glutamine Deprivation in U87MG Glioblastoma Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 60(4), pages 52845-52851, February.
    • Handle: RePEc:abf:journl:v:60:y:2025:i:4:p:52845-52851
    DOI: 10.26717/BJSTR.2025.60.009484
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    References listed on IDEAS

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    1. Manabu Kodama & Kiyotaka Oshikawa & Hideyuki Shimizu & Susumu Yoshioka & Masatomo Takahashi & Yoshihiro Izumi & Takeshi Bamba & Chisa Tateishi & Takeshi Tomonaga & Masaki Matsumoto & Keiichi I. Nakaya, 2020. "A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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      JEL classification:

      • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
      • Z0 - Other Special Topics - - General

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