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Melatonin Enhances the Efficacy of Cdk4/6 Inhibitor in Breast Cancer Cells Via Down-Regulating the Expression of Cyclind1

Author

Listed:
  • Zhumei Zhuang

    (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China)

  • Qing Tang
  • Miaomiao Gong
  • Jinjin Pan
  • Xiaocheng Yuan
  • Yuhui Yuan

    (The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116400, P. R. China)

Abstract

Breast Cancer (BC) is the most common malignancy and cause of death among women. CDK4/6 inhibitor-Palbociclib (PD) isethionate is a new chemotherapeutic agent in the treatment of breast cancer that works through blocking retinoblastoma phosphorylation protein and regulating the retinoblastoma (RB)-E2F pathway to inhibit cell cycle in the G0/G1 phase. However, the toxicity and resistance of PD are the primary limiting factors of this therapeutic effect. Melatonin (MLT) exerts anti-tumor activity in BC and arrests the cell cycle in the G0/G1 phase.

Suggested Citation

  • Zhumei Zhuang & Qing Tang & Miaomiao Gong & Jinjin Pan & Xiaocheng Yuan & Yuhui Yuan, 2024. "Melatonin Enhances the Efficacy of Cdk4/6 Inhibitor in Breast Cancer Cells Via Down-Regulating the Expression of Cyclind1," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 59(5), pages 51992-52004, December.
    • Handle: RePEc:abf:journl:v:59:y:2024:i:5:p:51992-52004
    DOI: 10.26717/BJSTR.2024.59.009367
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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