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Synthesis and In Silico Analysis of Chalcone Derivatives as Potential Prostaglandin Synthetase Inhibitors

Author

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  • Samuel J Bunu

    (Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria)

  • Oyeintonbara Miediegha

    (Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria)

  • Ebisindor V Awala

    (Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria)

  • Deghinmotei Alfred-Ugbenbo

    (Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Bayelsa Medical University, Nigeria)

  • Baba Haruna

    (Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Calabar, Nigeria)

  • Cyril O Usifoh

    (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria)

Abstract

Nine derivatives of chalcones were successfully synthesized using the Claisen- Schmidt condensation reaction between different derivatives of benzaldehyde and acetophenone at low temperature in the presence of potassium hydroxide (KOH) and ethanol. The compounds were obtained in high yield. The percentage yield ranges from 90.38 – 27.68%, with sample B having the highest yield while sample I gave lowest yield. Also, the infra-red and nuclear magnetic resonance (FTIR and NMR) spectroscopic analysis shows distinct spectrum across all molecules, indicating the presence of unique functional groups and chemical environments.

Suggested Citation

  • Samuel J Bunu & Oyeintonbara Miediegha & Ebisindor V Awala & Deghinmotei Alfred-Ugbenbo & Baba Haruna & Cyril O Usifoh, 2024. "Synthesis and In Silico Analysis of Chalcone Derivatives as Potential Prostaglandin Synthetase Inhibitors," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 55(2), pages 46709-46720, February.
    • Handle: RePEc:abf:journl:v:55:y:2024:i:2:p:46709-46720
    DOI: 10.26717/BJSTR.2024.55.008662
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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