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Axonal Transport Blockade in Abusive Head Trauma Suspects; A Mini Review

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  • Don Minckler

    (Recall Professor for Teaching, University of California Irvine, Emeritus Professor of Ophthalmology and Laboratory Medicine, USA)

Abstract

This report summarizes the application of Amyloid Beta Protein (APP-A4) immunohistochemistry to the study of ocular tissues from victims of suspected child abuse, aka Abusive Head Trauma (AHT). The two referenced publications summarize the history of AHT, its confusing terminology and tortured medico-legal issues. Additionally, they describe the ocular histopathology and Immunohistochemistry (IHC) utilizing (APP-A4), the only available antibody for human tissue analysis of orthograde axonal transport. The two publications include findings from 76 autopsied cases of suspected child abuse concentrating on retinal and optic nerve findings, especially the Lamina Cribrosa (LC) portion of the optic nerve. The first paper published discussed five cases judged to have unusual IHC findings, compared to prior personal experience [1].

Suggested Citation

  • Don Minckler, 2023. "Axonal Transport Blockade in Abusive Head Trauma Suspects; A Mini Review," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 54(1), pages 45475-45476, December.
    • Handle: RePEc:abf:journl:v:54:y:2023:i:1:p:45475-45476
    DOI: 10.26717/BJSTR.2023.54.008503
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