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Clinical Utility of Individualized Follow-Up in Acute Myeloid Leukemia (AML) Patients Using a Myeloid NGS Panel

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  • Marta Fernández Mercado

    (Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, Spain)

Abstract

The current standard to determine complete remission in acute myeloid leukemia (AML) includes morphologic criteria, cytogenetics, classical molecular analysis -such as polymerase chain reaction (PCR) and quantitative reverse-transcription PCR (RT-qPCR), and flow cytometry. Recently, NextGeneration Sequencing (NGS) is being a useful tool to gain insights into the molecular alterations in patients diagnosed with AML. We hypothesized that deeper knowledge of the clonal dynamics of AML could potentially be of clinical utility. We studied with our custom Pan-Myeloid NGS Panel the genomic alterations of 71 samples, corresponding to 20 AML cases during disease follow-up. Sequencing data identified genomic clonal markers with clinical utility in 90% of cases.

Suggested Citation

  • Marta Fernández Mercado, 2023. "Clinical Utility of Individualized Follow-Up in Acute Myeloid Leukemia (AML) Patients Using a Myeloid NGS Panel," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 53(3), pages 44727-44741, October.
    • Handle: RePEc:abf:journl:v:53:y:2023:i:3:p:44727-44741
    DOI: 10.26717/BJSTR.2023.53.008401
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