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Correlation between Serum Interleukin-8, Interleukin-6 Levels, and the Response to Anti-PD-1/PD-L1 Inhibitor in Patients with Malignant Tumors- A Prospective Observational Study

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  • Xi Tang

    (Oncology Department, Huadong Hospital, Fudan University, China)

Abstract

The programmed cell death (PD-1) receptor and its ligand (PDL1) are involved in an important immune checkpoint that helps keep the body›s immune responses in check [1]. Cancer cells can express PD-L1 and PD-L2, which can inhibit immune-modulatory T-cell activation and facilitate disease progression by targeting the PD-1 receptor [2-4]; thus, blocking either PD-1 or PD-L1 can prevent PD-1 activation, attenuating the immune tolerance and improving T cell-mediated killing of cancer cells [5,6].

Suggested Citation

  • Xi Tang, 2023. "Correlation between Serum Interleukin-8, Interleukin-6 Levels, and the Response to Anti-PD-1/PD-L1 Inhibitor in Patients with Malignant Tumors- A Prospective Observational Study," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 53(1), pages 44332-44339, October.
    • Handle: RePEc:abf:journl:v:53:y:2023:i:1:p:44332-44339
    DOI: 10.26717/BJSTR.2023.53.008349
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