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Activated Translation of HIF-1α mRNA as a Key Mechanism in Oncogenesis of Pancreatic Ductal Adenocarcinoma and Other Malignant Diseases

Author

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  • Mitsuru Sakitani

    (Director of the Institute CCC, Ibukidai-Higashimachi, Nishi ward, Kobe, Hyogo, Japan)

Abstract

Molecular targeted therapies against KRAS mutant pancreatic ductal adenocarcinoma (PDAC) remain insufficient. The most serious causes are supposed to be bypass activation of the PI3K/AKT/mTOR signaling pathway and crosstalk between mTOR and hypoxia inducible factor (HIF). This short review is aimed at clarifying the involvement of activated translation of HIF-1α mRNA in oncogenesis of KRAS mutant PDAC in association with CA9 activation.

Suggested Citation

  • Mitsuru Sakitani, 2023. "Activated Translation of HIF-1α mRNA as a Key Mechanism in Oncogenesis of Pancreatic Ductal Adenocarcinoma and Other Malignant Diseases," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 51(5), pages 43069-43072, July.
    • Handle: RePEc:abf:journl:v:51:y:2023:i:5:p:43069-43072
    DOI: 10.26717/BJSTR.2023.51.008156
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