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Methanol Fraction of Ethanol Extract of Dialium Guineense Stem Bark Mitigates STZ-Induced Oxidative Stress in Rat Liver

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  • Abu OD

    (Department of Biochemistry, Faculty of Life Sciences, University of Benin, Nigeria)

Abstract

The present study investigated the effect of methanol fraction of ethanol extract of Dialium guineense (MEDG) stem bark on streptozotocin (STZ)-induced oxidative stress in rat liver. Male albino rats of Wistar strain (n = 25, mean weight = 215 ± 15 g) were randomly assigned to five groups (5 rats/group): normal control, diabetic control, metformin, MEDG [200 mg/kg body weight (bwt)] and MEDG (300 mg/kg bwt) groups. Diabetes mellitus was induced in the rats via intraperitoneal injection of 50 mg/kg bwt STZ.

Suggested Citation

  • Abu OD, 2023. "Methanol Fraction of Ethanol Extract of Dialium Guineense Stem Bark Mitigates STZ-Induced Oxidative Stress in Rat Liver," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 51(2), pages 42594-42600, June.
  • Handle: RePEc:abf:journl:v:51:y:2023:i:2:p:42594-42600
    DOI: 10.26717/BJSTR.2023.51.008085
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