Peptic Ulcer and Role of a Polyherbal Formulation in Pathogenesis of Ulcer in Wistar Rats

Peptic ulcers are characterized by gastrointestinal tract mucosal erosions that may extend to the muscular layer. Their complex aetiology is brought on by an imbalance between the mucosa’s offensive and defensive components. Peptic ulcers, which afflict millions of people globally and have high rates of recurrence, are a major public health concern. The use of non-steroidal anti-inflammatory medicines (NSAIDs) and Helicobacter pylori infection are two of the most significant risk factors for the development of peptic ulcers. Up until the later decades of the 20th century, when epidemiological patterns started to indicate to an astonishing decline in its prevalence, peptic ulcer disease had a significant impact on morbidity and death. As a result, novel complementary treatment strategies are required to stop the onset of ulcers and their recurrence. In experimental models of peptic ulcers, natural products including medicinal plants and their extracted components have been frequently employed. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasised the idea of polyherbalism as a means of enhancing medicinal efficacy. Individual plants’ active phytochemical components are inadequate to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when several herbs are combined in a certain ratio. The importance of polyherbalism and its therapeutic value are primarily the subject of this review.