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Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions

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  • Arunachalam Muthuraman

    (Department of Pharmacology, Faculty of Pharmacy, AIMST University, 08100-Bedong, Kedah D.A, Malaysia)

Abstract

Rutin is a bioflavonoid and plant pigment. It is found in various fruits and vegetables. Chemically, it is known as rutoside, quercetin-3-O-rutinoside, sophorin, and vitamin P. It has antioxidant, anti-inflammatory, and immunomodulation-associated neuroprotective and anti- Alzheimer actions. The role of rutin against glyphosate-induced cognitive dysfunction in adult zebrafish has not been studied yet. The present study focused on the role of rutin on glyphosate- induced cognitive dysfunction in adult zebrafish. The glyphosate (GYP, 0.5 mg/L), rutin (50, 100, and 150 µg/L), and donepezil (DP, 1 µg/mL) for 30 minutes/day were exposed for 14 consecutive days.

Suggested Citation

  • Arunachalam Muthuraman, 2023. "Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 50(4), pages 41794-41802, May.
    • Handle: RePEc:abf:journl:v:50:y:2023:i:4:p:41794-41802
    DOI: 10.26717/BJSTR.2023.50.007974
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