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Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R

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  • Pei-Yuan Sun
  • Jing Wang

    (Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, China)

Abstract

Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in EGFR-driven nonsmall cell lung cancer (NSCLC) development, and molecular targeted therapies have focused on inhibiting these mutations. EGFR tyrosine kinase inhibitors (TKIs) have remarkable inhibitory effect for NSCLC with EGFR mutations. However, acquired resistance limited the clinical application of EGFR-TKIs, which highlights the need for discovery of novel inhibitors. In this study, we created Ba/F3 cells harboring EGFR L858R/T790M/G796R mutations, and then found magnolol effectively inhibited EGFR L858R/T790M/ C797S activation, which may be a potential strategy against osimertinib-resistant EGFR mutations.

Suggested Citation

  • Pei-Yuan Sun & Jing Wang, 2023. "Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 50(3), pages 41660-41666, May.
    • Handle: RePEc:abf:journl:v:50:y:2023:i:3:p:41660-41666
    DOI: 10.26717/BJSTR.2023.50.007953
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