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Investigation of a Novel Biocompatible Fast-Gelling Hydrogel for Neurodegenerative Diseases

Author

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  • Song Jiang

    (Department of Biochemistry, Huzhou Institute Of Biological Products Co., Ltd. China)

Abstract

A novel biocompatible fast-gelling hydrogel has been explored for neurodegenerative diseases. The hydrogel is formed using thiol-maleimide reaction. The precursors maleimide modified 4-arm polyethylene glycol (PEG) and thiolated hyaluronic acid (HA) were created and characterized by NMR. The hydrogel was investigated by the measurement of gelation time, swelling ratio, viscoelasticity and degradation. Based on the data of gelation time, we found that the hydrogel with two percent maleimide modified 4-arm PEG and thiolated HA was most appropriate for tuning. This percentage of hydrogel was selected for other tests. The tests of swelling ratio and degradation indicated hydrogel was flexible and degradable. The viscoelasticity test revealed that the hydrogel is an elastic solid. From these measurements, this novel biocompatible fastgelling hydrogel could be used for the treatment of neurodegenerative diseases.

Suggested Citation

  • Song Jiang, 2023. "Investigation of a Novel Biocompatible Fast-Gelling Hydrogel for Neurodegenerative Diseases," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 50(3), pages 41647-41653, May.
    • Handle: RePEc:abf:journl:v:50:y:2023:i:3:p:41647-41653
    DOI: 10.26717/BJSTR.2023.50.007951
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