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Evaluation of Aqueous Nanoformulations of Epigallocatechin-3-Gallate-Palmitate (EC16) Against Human Coronavirus as a Potential Intervention Drug

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  • Stephen Hsu

    (Augusta University, Augusta, USA)

Abstract

Chronic neurologic diseases are common sequelae of COVID. They severely impact the quality of life and increase the burden on healthcare systems. The long COVID neurological symptoms are due to the robust replication of SARS-CoV-2 in the nasal neuroepithelial cells, leading to neuroinvasion, persistent infection, and inflammation of the central nerve system (CNS). Currently used medications and vaccines do not inhibit SARS-CoV-2 replication in the nasal epithelial cells nor the persistent infection. EGCG-palmitate (EC16), a multifunctional compound, has the potential to become a novel intranasaldelivered drug for minimizing post-COVID neurologic symptoms. However, EC16 is a hydrophobic, water insoluble compound. Therefore, formulation strategies were explored as a first step to developing aqueous delivery forms of EC16.

Suggested Citation

  • Stephen Hsu, 2023. "Evaluation of Aqueous Nanoformulations of Epigallocatechin-3-Gallate-Palmitate (EC16) Against Human Coronavirus as a Potential Intervention Drug," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 50(1), pages 41242-41253, April.
    • Handle: RePEc:abf:journl:v:50:y:2023:i:1:p:41242-41253
    DOI: 10.26717/BJSTR.2023.50.007892
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