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Clinical Application of Therapeutic Bispecific Antibodies

Author

Listed:
  • Girum Tefera Belachew

    (Department of Biotechnology, College of Natural and Computational Sciences, Debre Birhan University, Ethiopia)

Abstract

Bispecific antibodies (BsAbs) have been developed, with one antigen-binding site coordinated against the CD3 receptor (which activates cytotoxic T lymphocytes) and the other against specific antigens found on cancer cells (CD19, CD20, CD33, CD123, HER2, epithelial cell adhesion molecule [EpCAM], BCMA, CEA, and others). Bispecific antibodies (BsAbs) are unique immunological constructs that frequently recognize two distinct target antigens from multiple proteins.

Suggested Citation

  • Girum Tefera Belachew, 2023. "Clinical Application of Therapeutic Bispecific Antibodies," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 49(5), pages 41145-41153, April.
    • Handle: RePEc:abf:journl:v:49:y:2023:i:5:p:41145-41153
    DOI: 10.26717/BJSTR.2023.49.007880
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