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Stem Cell Therapy for Regeneration of Radiated Salivary Glands

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  • Ola M Ezzatt

    (Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain-Shams University, Cairo, Egypt)

Abstract

Radiation used in the treatment of head and neck cancer causes significant damage to the salivary glands and a loss of salivary function. Current therapies for radiation-induced salivary hypofunction aimed to stimulate residual functional salivary gland tissues and treat the symptoms of xerostomia without restoring the lost tissue. Several research strategies are emerging, aimed at regenerating salivary glands damaged by radiation via either gene therapy or by transplantation of stem cells. This concise review focuses on cell-based therapeutic strategies for regeneration of irradiated salivary gland (SG) tissues and discuss the possible regenerative potentials and applications of GMSCs in this context.

Suggested Citation

  • Ola M Ezzatt, 2023. "Stem Cell Therapy for Regeneration of Radiated Salivary Glands," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 49(5), pages 41123-41128, April.
    • Handle: RePEc:abf:journl:v:49:y:2023:i:5:p:41123-41128
    DOI: 10.26717/BJSTR.2023.49.007876
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