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Last Days Stage or Something Else?

Author

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  • Alicia Cárdenas García

    (Villalba General Hospital, Spain)

Abstract

JPH203 is a selective LAT1 inhibitor designed to significantly reduce essential uptake and induce apoptosis by the mitochondria-dependent intrinsic apoptotic signalling pathway. A phase II active metabolite of JPH203 is N-acetyl JPH203. Herein, we report the synthesis and characterization of deuterium labelled d5 -JPH203 and d3 -N-acetyl JPH203. JPH203 is currently in Phase II clinical trials. These compounds have been successfully used as internal standards for liquid chromatography mass spectrometry-mass spectrometry (LC/MS-MS) from biological samples. Comprising fifteen steps, the synthesis of d5-JPH203 utilizes d5 -benzoyl chloride. Whereas d3 -acetyl JPH203 uses d3-acetylchloride and prepared in eighteen synthetic steps.

Suggested Citation

  • Alicia Cárdenas García, 2023. "Last Days Stage or Something Else?," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 49(4), pages 40813-40814, March.
    • Handle: RePEc:abf:journl:v:49:y:2023:i:4:p:40813-40814
    DOI: 10.26717/BJSTR.2023.49.007823
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