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The Role of Pancreatic Stellate Cells in the Repair of Pancreatic Injury

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  • Zhou Wence

    (The Second Hospital of Lanzhou University, China)

Abstract

When pancreatic tissue is damaged by external force or inflammation, it initiates its own repair process. Like most tissue damage repair, the repair process of pancreatic injury also includes the repair of cellular and interstitial components. The repair of cell components is achieved through cell division and proliferation, while the repair of interstitial components is mainly completed through the secretion of extracellular matrix (ECM). As the main cellular component of pancreatic tissue, pancreatic stellate cells (PSCs) participate in the secretion of ECM and the differentiation and proliferation of other pancreatic parenchymal cells through various pathways. A large number of studies have confirmed that the activation of PSC plays an important role in the repair of pancreatic injury. Based on a large number of literature study, this paper summarizes the current research progress on the mechanism of PSC in the repair of pancreatic injury, in order to provide new directions and ideas for the basic research and clinical diagnosis and treatment of pancreatic injury

Suggested Citation

  • Zhou Wence, 2023. "The Role of Pancreatic Stellate Cells in the Repair of Pancreatic Injury," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 49(3), pages 40657-40664, March.
    • Handle: RePEc:abf:journl:v:49:y:2023:i:3:p:40657-40664
    DOI: 10.26717/BJSTR.2023.49.007800
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