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Impairing Dopaminergic Cells in Olfactory Bulb Decreases Number of the Dopaminergic Cells in Substantial Nigra of Rats

Author

Listed:
  • Irami Araújo-FilhoYan Huang
  • Haichen Niu
  • Deqin Geng

    (Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, PR China)

Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by the massive loss of midbrain dopaminergic neurons with the motor impairments. However, a popular of hyposmia and olfactory dysfunction are found before the onset of motor impairments. It’s known that the olfactory system is the only organ that can directly contact with the environment, which is easily affected by environmental toxin than other organs. However, it’s unclear that damaging olfaction can induce the pathological response of the dopaminergic cells in the nigrostriatal system resulting in the impairment of motor.

Suggested Citation

  • Irami Araújo-FilhoYan Huang & Haichen Niu & Deqin Geng, 2023. "Impairing Dopaminergic Cells in Olfactory Bulb Decreases Number of the Dopaminergic Cells in Substantial Nigra of Rats," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 49(2), pages 40429-40436, March.
    • Handle: RePEc:abf:journl:v:49:y:2023:i:2:p:40429-40436
    DOI: 10.26717/BJSTR.2023.49.007771
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