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Monoclonal B-Cell Lymphocytosis- Compromise of the Immune System?

Author

Listed:
  • Mike A Celis

    (University of Santander, Faculty of Medical and Health Sciences, Masira Research Institute, Colombia
    Universidad del Valle, Faculty of Health, Ph.D. in Biomedical Sciences, Colombia)

  • Wendy Nieto

    (International Hospital of Colombia, Department of Pathology, FCV Translational Biomedical Research Group, Colombia)

Abstract

Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% of older adults age 40 and the incidence increases with aging [2,3], MBL is widely associated as one of the main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL), since studies Prospective cohort studies verified, in effect, that CLL is always preceded by MBL, therefore, the greater the number of clonal B cells, the greater the risk of developing this type of cancer [4]. However, it is not ruled out that MBL is implicated in the lymphomagenesis of other pathologies such as follicular lymphoma and mantle cell lymphoma [5].

Suggested Citation

  • Mike A Celis & Wendy Nieto, 2023. "Monoclonal B-Cell Lymphocytosis- Compromise of the Immune System?," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 48(4), pages 40013-40014, February.
    • Handle: RePEc:abf:journl:v:48:y:2023:i:4:p:40013-40014
    DOI: 10.26717/BJSTR.2023.48.007698
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