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Leprosy Overview: Pathophysiology, Immune Responses, and Epidemiology in Brazil

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  • Manuela B Pucca

    (Health Sciences Postgraduate Program, Federal University of Roraima, Brazil
    Medical School, Federal University of Roraima, Brazil)

Abstract

Leprosy is an infectious disease caused by a parasite, known as Mycobacterium leprae, able to infect cells from peripheral nerves, leading to a high disabling power due to neural impairment. This pathology is common in more than 120 countries, with more than 100,000 cases occurring every year. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the most limited presentations and the Th2 to the most disseminated ones. Due to the clinical and histopathological diversity of the disease, the immunopathogenesis of leprosy is not completely understood. Our review describes the role of the immune system in the pathogenesis of leprosy aiming to understand the mechanisms involved in the development of the different immune responses against the disease.

Suggested Citation

  • Manuela B Pucca, 2023. "Leprosy Overview: Pathophysiology, Immune Responses, and Epidemiology in Brazil," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 48(4), pages 39867-39875, February.
    • Handle: RePEc:abf:journl:v:48:y:2023:i:4:p:39867-39875
    DOI: 10.26717/BJSTR.2023.48.007676
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