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Identification of Potential Kinase Inhibitors to Specifically Target Mkk4 for Skin Tumorigenesis

Author

Listed:
  • Deepak Saravanan
  • Monisha Mohan

    (Department of Science and Humanities, Indian Institute of Information Technology, Design and Manufacturing, Kancheepuram, India)

Abstract

MKK4, a Ser/Thr protein kinase, is one of the critical activators of MAP kinases in response to various mitogenic stimuli. MKK4 induces skin tumorigenesis through oncogenic activation of the ras gene. The MKK4 acts as the main component of JNK activation which directly induces the RAS signaling pathway

Suggested Citation

  • Deepak Saravanan & Monisha Mohan, 2023. "Identification of Potential Kinase Inhibitors to Specifically Target Mkk4 for Skin Tumorigenesis," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 48(2), pages 39539-39547, January.
    • Handle: RePEc:abf:journl:v:48:y:2023:i:2:p:39539-39547
    DOI: 10.26717/BJSTR.2023.48.007628
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