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Inhibition of Autophagy Amplify Endoplasmic Reticulum Stress Dependent Cell Death in Cancer Cells

Author

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  • Prasun Guha

    (Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine and Institute of Marine and Environmental Technology, USA
    Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV 89154, USA)

  • Hafiz Ahmed

    (Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine and Institute of Marine and Environmental Technology, USA
    GlycoMantra, Inc., 1450 South Rolling Road, Baltimore, MD 21227, USA)

Abstract

Tunicamycin mediated induction of endoplasmic reticulum (ER) stress promotes cell death of cancer cells. However, the apoptotic doses of tunicamycin shows immense toxicity to normal cells and thus limits its use as a cancer chemotherapeutic

Suggested Citation

  • Prasun Guha & Hafiz Ahmed, 2022. "Inhibition of Autophagy Amplify Endoplasmic Reticulum Stress Dependent Cell Death in Cancer Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 47(4), pages 38819-38828, December.
  • Handle: RePEc:abf:journl:v:47:y:2022:i:4:p:38819-38828
    DOI: 10.26717/BJSTR.2022.47.007545
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