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Force Degradation Study of Rizatriptan Benzoate by RpHPLC Method and Characterization of Degraded Product

Author

Listed:
  • Pritam S Jain
  • Harshal P Chaudhari
  • Gayatri B Patil
  • Sanjay J Surana

    (RC Patel Institute of Pharmaceutical Education and Research, India)

Abstract

he objective of the work was to study the degradation behavior of rizatriptan benzoate under different ICH recommended stress conditions by HPLC, and to establish a validated stability indicating LC assay method. Rizatriptan benzoate was subjected to stress conditions of hydrolysis and oxidation decomposition. Extensive degradation was found to occur in acidic medium...

Suggested Citation

  • Pritam S Jain & Harshal P Chaudhari & Gayatri B Patil & Sanjay J Surana, 2017. "Force Degradation Study of Rizatriptan Benzoate by RpHPLC Method and Characterization of Degraded Product," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 1(5), pages 1456-1462, October.
    • Handle: RePEc:abf:journl:v:1:y:2017:i:5:p:1456-1462
    DOI: 10.26717/BJSTR.2017.01.000461
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    More about this item

    Keywords

    Biomedical Sciences; Biomedical Research; Technical research Rizatriptan Benzoate; Rp-Hplc; Validation; Purity Evaluation; Degradation Product;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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