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Star Scientists, Institutions, and the Entry of Japanese Biotechnology Enterprises

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Author Info
Michael R. Darby
Lynne G. Zucker

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Abstract

Advance of science and its commercial applications are in a close, symbiotic relationship in the U.S. biotechnology industry. Comparing Japan and the U.S., the structure of the science appears broadly similar, but the organization of the biotechnology industry is quite dissimilar. In the U.S., some 77 percent of new biotechnology enterprises (NBEs) were dedicated new biotechnology firms (NBFs) started for this purpose while 88 percent of Japanese biotech firms in our data base were subunits of existing firms (NBSs). We report pooled poisson regression estimates of the relation of NBE births in Japan to top-producing is at work in Japan and America, stars in Japan induce entry of significantly fewer NBEs than in the U.S. and preexisting economic activity plays a greater role. We find no such significant difference for entry of keiretsu-member and nonmember firms within Japan. We relate the significant Japan-U.S. differences to Japan's relatively compact geography and institutional differences between the higher-education and research funding systems, the venture-capital and IPO markets, cultural characteristics and incentive systems which impact scientists' entrepreneurialism, and tort-liability exposures. The relative importance of these factors and whether differences in organization of biotechnology result in substantial differences in productivity and international competitiveness are issues for future research.

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Paper provided by National Bureau of Economic Research, Inc in its series NBER Working Papers with number 5795.

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Date of creation: Oct 1996
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Handle: RePEc:nbr:nberwo:5795

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Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:

  1. Lynne G. Zucker & Michael R. Darby & Jeff Armstrong, 1999. "Intellectual Capital and the Firm: The Technology of Geographically Localized Knowledge Spillovers," NBER Working Papers 4946, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
  2. Lynne G. Zucker & Michael R. Darby & Marilynn B. Brewer, 1999. "Intellectual Capital and the Birth of U.S. Biotechnology Enterprises," NBER Working Papers 4653, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
  3. Lynne Zucker & Michael Darby, 1994. "The Organization of Biotechnology Science and Its Commercialization in Japan," Institute for Social Science Research, Working Paper Series issr-1000, Institute for Social Science Research, UCLA. [Downloadable!]
  4. Zucker, Lynne G & Darby, Michael R & Brewer, Marilynn B, 1998. "Intellectual Human Capital and the Birth of U.S. Biotechnology Enterprises," American Economic Review, American Economic Association, vol. 88(1), pages 290-306, March. [Downloadable!] (restricted)
  5. Wooldridge, Jeffrey M., 1991. "On the application of robust, regression- based diagnostics to models of conditional means and conditional variances," Journal of Econometrics, Elsevier, vol. 47(1), pages 5-46, January. [Downloadable!] (restricted)
  6. Steven Klepper & Elizabeth Graddy, 1990. "The Evolution of New Industries and the Determinants of Market Structure," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 27-44, Spring. [Downloadable!] (restricted)
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(explanations, Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.)

  1. Gatti, Anna & Vendelø , Morten Thanning, 2005. "The Impact of Institutional Settings on Learning Behavior by Venture Capitalists and Start-Ups," Working Papers 2005-5, Copenhagen Business School, Department of Informatics. [Downloadable!]
  2. Lynne G. Zucker & Michael R. Darby & Yusheng Peng, 1998. "Fundamentals or Population Dynamics and the Geographic Distribution of U.S. Biotechnology Enterprises, 1976-1989," NBER Working Papers 6414, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
  3. Peaucelle, Irina, 1998. "Firms innovation activity and patenting : Russian case in mind," CEPREMAP Working Papers (Couverture Orange) 9809, CEPREMAP. [Downloadable!]
  4. Lynne G. Zucker & Michael R. Darby, 1998. "Capturing Technological Opportunity via Japan's Star Scientists: Evidence from Japanese Firms' Biotech Patents and Products," NBER Working Papers 6360, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
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  5. Sambidi, Pramod & Harrison, Wes, 2006. "Spatial Clustering of the U.S. Biotech Industry," 2006 Annual meeting, July 23-26, Long Beach, CA 21360, American Agricultural Economics Association (New Name 2008: Agricultural and Applied Economics Association). [Downloadable!]
  6. Lynne G. Zucker & Michael R. Darby & Maximo Torero, 1997. "Labor Mobility from Academe to Commerce," NBER Working Papers 6050, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
    Other versions:
  7. Yusheng Peng & Lynne G. Zucker & Michael R. Darby, 1997. "Chinese Rural Industrial Productivity and Urban Spillovers," NBER Working Papers 6202, National Bureau of Economic Research, Inc. [Downloadable!] (restricted)
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