Paul C. Lambert (Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK) Lucinda J. Billingham (Cancer Research UK Clinical Trials Unit, University of Birmingham, UK) Nicola J. Cooper (Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK) Alex J. Sutton (Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK) Keith R. Abrams (Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK)
Abstract
There is an increasing need to establish whether health-care interventions are cost effective as well as clinically effective. It is becoming increasingly common for cost studies to be incorporated into clinical trials, either on all patients or more usually on a subset of patients. Establishing the total cost per patient is complex, as it requires information on resource use, which may come from a variety of different sources. This complexity may lead to considerable missing data, and can result in some patients only having partial cost information.
In this paper we consider a clinical trial consisting of 351 patients with advanced non-small cell lung cancer comparing chemotherapy with standard palliative care. A subset of 115 patients was selected for the cost sub-study. Total cost was split into four components, for which resource use was collected. Complete resource data were available on 82 patients. For the remaining patients at least one of the cost components was missing.
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Article provided by John Wiley & Sons, Ltd. in its journal Health Economics.
Volume (Year): 17 (2008) Issue (Month): 1 () Pages: 67-81 Download reference. The following formats are available: HTML,
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