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Field Theory of a Reaction-Diffusion Model of Quasispecies Dynamics

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  • Romualdo Pastor-Satorras
  • Ricard V. Solé

Abstract

RNA viruses are known to replicate with extremely high mutation rates. These rates are actually close to the so-called error threshold. This threshold is in fact a critical point beyond which genetic information is lost through a second-order phase transition, which has been dubbed the ``error catastrophe.'' Here we explore this phenomenon using a field theory approximation to the spatially extended Swetina-Schuster quasispecies model [J. Swetina and P. Schuster, Biophys. Chem. 16, 329 (1982)], a single-sharp-peak landscape. In analogy with standard absorbing-state phase transitions, we develop a reaction-diffusion model whose discrete rules mimic the Swetina-Schuster model. The field theory representation of the reaction-diffusion system is constructed. The proposed field theory belongs to the same universality class than a conserved reaction-diffusion model previously proposed [F. van Wijland et al., Physica A251, 179 (1998)]. From the field theory, we obtain the full set of exponents that characterize the critical behavior at the error threshold. Our results present the error catastrophe from a new point of view and suggest that spatial degrees of freedom can modify several mean field predictions previously considered, leading to the definition of characteristic exponents that could be experimentally measurable.

Suggested Citation

  • Romualdo Pastor-Satorras & Ricard V. Solé, 2001. "Field Theory of a Reaction-Diffusion Model of Quasispecies Dynamics," Working Papers 01-05-024, Santa Fe Institute.
  • Handle: RePEc:wop:safiwp:01-05-024
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    1. Cohen, Joel E. & Hajnal, John & Newman, Charles M., 1986. "Approaching consensus can be delicate when positions harden," Stochastic Processes and their Applications, Elsevier, vol. 22(2), pages 315-322, July.
    2. Follmer, Hans, 1974. "Random economies with many interacting agents," Journal of Mathematical Economics, Elsevier, vol. 1(1), pages 51-62, March.
    3. Orlean, Andre, 1995. "Bayesian interactions and collective dynamics of opinion: Herd behavior and mimetic contagion," Journal of Economic Behavior & Organization, Elsevier, vol. 28(2), pages 257-274, October.
    4. H. Peyton Young & Mary A. Burke, 2001. "Competition and Custom in Economic Contracts: A Case Study of Illinois Agriculture," American Economic Review, American Economic Association, vol. 91(3), pages 559-573, June.
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