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Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration

Author

Listed:
  • Erno Hermans
  • Hein van Marle
  • Lindsey Ossewaarde
  • Marloes Henckens

    (Radboud University [Nijmegen], McGill University = Université McGill [Montréal, Canada])

  • Shaozheng Qin

    (Stanford School of Medicine [Stanford] - Stanford Medicine - Stanford University)

  • Marlieke van Kesteren
  • Vincent Schoots
  • Helena Cousijn
  • Mark Rijpkema

    (Donders Institute for Brain, Cognition and Behaviour - Radboud University [Nijmegen])

  • Robert Oostenveld

    (Donders Institute for Brain, Cognition and Behaviour - Radboud University [Nijmegen])

  • Guillén Fernández

    (Department of Psychiatry - Department of Psychiatry)

Abstract

Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes. β-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting.

Suggested Citation

  • Erno Hermans & Hein van Marle & Lindsey Ossewaarde & Marloes Henckens & Shaozheng Qin & Marlieke van Kesteren & Vincent Schoots & Helena Cousijn & Mark Rijpkema & Robert Oostenveld & Guillén Fernández, 2011. "Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration," Post-Print hal-03188207, HAL.
    • Handle: RePEc:hal:journl:hal-03188207
    DOI: 10.1126/science.1209603
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    1. repec:osf:osfxxx:fqmdu_v1 is not listed on IDEAS
    2. Hongbo Yu & Xi Chen & Jinting Liu & Xiaolin Zhou, 2013. "Gum Chewing Inhibits the Sensory Processing and the Propagation of Stress-Related Information in a Brain Network," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    3. Shields, Grant S. & Malone, Trey, 2025. "A narrative review of stress, food choices, and eating behavior: Integrating psychoneuroendocrinology and economic decision-making," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 119(C).

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