IDEAS home Printed from
   My bibliography  Save this paper

Modeling of immune life history and body growth: the role of antigen burden


  • Sergey G. Rudnev
  • Alexei A. Romanyukha

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Anatoli I. Yashin

    (Max Planck Institute for Demographic Research, Rostock, Germany)


In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune system. The treatise is based on the assumption of linear dependence of antigen load from basal metabolic rate, which, in turn, depends on body mass following the allometric relationship – 3/4 power scaling law (Kleiber, 1932; West, Brown, 2005). Energy cost of antigen burden, i.e. the energy needed to produce and maintain immune cells plus the energy loss due to infectious diseases, is estimated and used as a measure of the immune system effectiveness. The dependence of optimal resource allocation from the parameters of antigen load is studied.

Suggested Citation

  • Sergey G. Rudnev & Alexei A. Romanyukha & Anatoli I. Yashin, 2006. "Modeling of immune life history and body growth: the role of antigen burden," MPIDR Working Papers WP-2006-042, Max Planck Institute for Demographic Research, Rostock, Germany.
  • Handle: RePEc:dem:wpaper:wp-2006-042

    Download full text from publisher

    File URL:
    Download Restriction: no

    More about this item

    JEL classification:

    • J1 - Labor and Demographic Economics - - Demographic Economics
    • Z0 - Other Special Topics - - General

    NEP fields

    This paper has been announced in the following NEP Reports:


    Access and download statistics


    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:dem:wpaper:wp-2006-042. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Peter Wilhelm). General contact details of provider: .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.