A case-only approach for assessing gene-sex interaction in human longevity
As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)
When requesting a correction, please mention this item's handle: RePEc:dem:wpaper:wp-2001-012. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Peter Wilhelm)
If references are entirely missing, you can add them using this form.