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A case-only approach for assessing gene-sex interaction in human longevity

  • Qihua Tan

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Anatoli I. Yashin

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Else M. Bladbjerg
  • Moniek De Maat
  • Karen Andersen-Ranberg
  • Bernard Jeune
  • Kaare Christensen
  • James W. Vaupel

    (Max Planck Institute for Demographic Research, Rostock, Germany)

Registered author(s):

    As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)

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    File URL: http://www.demogr.mpg.de/Papers/Working/wp-2001-012.pdf
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    Paper provided by Max Planck Institute for Demographic Research, Rostock, Germany in its series MPIDR Working Papers with number WP-2001-012.

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    Date of creation: May 2001
    Date of revision:
    Handle: RePEc:dem:wpaper:wp-2001-012
    Contact details of provider: Web page: http://www.demogr.mpg.de/

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