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A case-only approach for assessing gene-sex interaction in human longevity

Author

Listed:
  • Qihua Tan

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Anatoli I. Yashin

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Else M. Bladbjerg
  • Moniek De Maat
  • Karen Andersen-Ranberg
  • Bernard Jeune
  • Kaare Christensen
  • James W. Vaupel

    (Max Planck Institute for Demographic Research, Rostock, Germany)

Abstract

As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)

Suggested Citation

  • Qihua Tan & Anatoli I. Yashin & Else M. Bladbjerg & Moniek De Maat & Karen Andersen-Ranberg & Bernard Jeune & Kaare Christensen & James W. Vaupel, 2001. "A case-only approach for assessing gene-sex interaction in human longevity," MPIDR Working Papers WP-2001-012, Max Planck Institute for Demographic Research, Rostock, Germany.
    • Handle: RePEc:dem:wpaper:wp-2001-012
    DOI: 10.4054/MPIDR-WP-2001-012
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    JEL classification:

    • J1 - Labor and Demographic Economics - - Demographic Economics
    • Z0 - Other Special Topics - - General

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