A Three-Layer Model of the Mechanical Behaviour of Blood Vessel Walls

In this paper, the development of blood vessel mechanics and the remodeling of blood vessels are mainly introduced. Understanding the mechanical response of blood vessels to physiologic loads is necessary before ideal therapeutic solutions can be realized. Analytic results can help physicians in the clinic, both in designing and in choosing appropriate therapies. For this reason, blood vessel wall’s mechanical model was constructured by the intimal, medial, and adventitial layers. These illustrate how different types fo vessel exhibit different non-linear behaviour. The models include both mechanical and biochemical aspects of the vessel wall behaviou, which will enable the mocle to be used to simulate more advanced behaviour such as local autoregulatory processes.In an effort to bridge the gape between theoretically based vascular mechanics and simpler, clinically relevant compliance models, and alternative complementary energy formulation as well as improved experimental method are proposed. In this paper, dynamic fluid-structure interation using finite element method was adapted. The validated system and the new formulation show great potential for exploiting the benefits of innovative experimental design and statistically reliable data analysis. This analysis allows for a wide range of different types of blood vessel to be captured within a single model, allowing for different wall thichknesses and different proportions of intimal, medial and advaentitial layers.