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An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses

In: Applied Advanced Analytics

Author

Listed:
  • Taranga Mukherjee

    (University of Calcutta)

  • Rahul Bhattacharya

    (University of Calcutta)

  • Atanu Biswas

    (Indian Statistical Institute)

Abstract

Circular or directional outcomes are natural responses in many clinical trials (e.g. orthopedics, ophthalmology, sports medicine). Traditionally, clinical trials use equal allocation throughout the trial without utilizing the information contained in the sequentially observed responses in the running trial. Adaptive allocation designs are data-dependent alternatives to assign a greater number of subjects to the better performing treatments using the available data of the running trial in a convenient way. However, adaptive designs for circular responses are rare and, therefore, in the current work, we develop a multi-treatment response-adaptive randomization for circular treatment outcomes considering both the ethics and efficiency requirements. Apart from assessing the proposed allocation design empirically, the applicability of the design in real clinical trials is also enumerated from a practitioner’s viewpoint.

Suggested Citation

  • Taranga Mukherjee & Rahul Bhattacharya & Atanu Biswas, 2021. "An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses," Springer Proceedings in Business and Economics, in: Arnab Kumar Laha (ed.), Applied Advanced Analytics, pages 147-156, Springer.
    • Handle: RePEc:spr:prbchp:978-981-33-6656-5_13
    DOI: 10.1007/978-981-33-6656-5_13
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