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FRAGILITY: Stata module to compute the fragility index and quotient

Author

Listed:
  • Ariel Linden

    (Linden Consulting Group, LLC)

Programming Language

Stata

Abstract

fragility computes both the fragility index as described in Walsh et al. (2014) and the fragility quotient as proposed by Ahmed et al. (2016). The fragility index represents the absolute number of additional events (primary endpoints) required to obtain a P-value greater than or equal to a predetermined statistical significance threshold (typically set to 0.05). The fragility index is computed by adding an event to the group with the smaller number of events (and subtracting a non-event from the same group to keep the total number of patients constant) and recomputing the two-sided significance test (either Fisher's exact test or Pearson's chi-squared test). Events are iteratively added until the first time the computed P-value becomes equal to or greater than the desired level(). The fragility quotient is a relative measure of fragility which simply divides the absolute fragility index by the total sample size (Ahmed et al. 2016).

Suggested Citation

  • Ariel Linden, 2019. "FRAGILITY: Stata module to compute the fragility index and quotient," Statistical Software Components S458708, Boston College Department of Economics.
    • Handle: RePEc:boc:bocode:s458708
    Note: This module should be installed from within Stata by typing "ssc install fragility". The module is made available under terms of the GPL v3 (https://www.gnu.org/licenses/gpl-3.0.txt). Windows users should not attempt to download these files with a web browser.
    as

    Download full text from publisher

    File URL: http://fmwww.bc.edu/repec/bocode/f/fragility.ado
    File Function: program code
    Download Restriction: no
    File URL: http://fmwww.bc.edu/repec/bocode/f/fragility.sthlp
    File Function: help file
    Download Restriction: no
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