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Nonlinearities in Drug Release Process from Polymeric Microparticles: Long‐Time‐Scale Behaviour

Author

Listed:
  • Elena Simona Bacaita
  • Costica Bejinariu
  • Borsos Zoltan
  • Catalina Peptu
  • Gabriela Andrei
  • Marcel Popa
  • Daniela Magop
  • Maricel Agop

Abstract

A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built. As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field. This indicates that, in the case of long‐time‐scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration. The model is validated by experimental results.

Suggested Citation

  • Elena Simona Bacaita & Costica Bejinariu & Borsos Zoltan & Catalina Peptu & Gabriela Andrei & Marcel Popa & Daniela Magop & Maricel Agop, 2012. "Nonlinearities in Drug Release Process from Polymeric Microparticles: Long‐Time‐Scale Behaviour," Journal of Applied Mathematics, John Wiley & Sons, vol. 2012(1).
    • Handle: RePEc:wly:jnljam:v:2012:y:2012:i:1:n:653720
    DOI: 10.1155/2012/653720
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    References listed on IDEAS

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    1. Villalobos, Rafael & Cordero, Salomón & Maria Vidales, Ana & Domínguez, Armando, 2006. "In silico study on the effects of matrix structure in controlled drug release," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 367(C), pages 305-318.
    2. Villalobos, Rafael & Domínguez, Armando & Ganem, Adriana & Vidales, Ana Maria & Cordero, Salomón, 2009. "One-dimensional drug release from finite Menger sponges: In silico simulation," Chaos, Solitons & Fractals, Elsevier, vol. 42(5), pages 2875-2884.
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    Cited by:

    1. Carmen Nejneru & Anca Nicuţă & Boris Constantin & Liliana Rozemarie Manea & Mirela Teodorescu & Maricel Agop, 2013. "Dynamics Control of the Complex Systems via Nondifferentiability," Journal of Applied Mathematics, John Wiley & Sons, vol. 2013(1).

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