A dynamic multistate model of robustness and frailty
Dynamic multistate models can show realistic population dynamics over time, model complex cycles, and encompass the life history of a cohort. This paper uses a recently developed approach to obtain the analytic solution of a time-dependent multidimensional differential equation. The illustrative robust/frail model presented shows that the assumption of fixed individual frailty can be abandoned in a two living state model that allows transitions between health statuses and nonproportional hazards of death.
Volume (Year): 8 (2000)
Issue (Month): 4 ()
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