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Copula Link-Based Additive Models for Right-Censored Event Time Data

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  • Giampiero Marra
  • Rosalba Radice

Abstract

This article proposes an approach to estimate and make inference on the parameters of copula link-based survival models. The methodology allows for the margins to be specified using flexible parametric formulations for time-to-event data, the baseline survival functions to be modeled using monotonic splines, and each parameter of the assumed joint survival distribution to depend on an additive predictor incorporating several types of covariate effects. All the model’s coefficients as well as the smoothing parameters associated with the relevant components in the additive predictors are estimated using a carefully structured efficient and stable penalized likelihood algorithm. Some theoretical properties are also discussed. The proposed modeling framework is evaluated in a simulation study and illustrated using a real dataset. The relevant numerical computations can be easily carried out using the freely available GJRM R package. Supplementary materials for this article are available online.

Suggested Citation

  • Giampiero Marra & Rosalba Radice, 2020. "Copula Link-Based Additive Models for Right-Censored Event Time Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 115(530), pages 886-895, April.
    • Handle: RePEc:taf:jnlasa:v:115:y:2020:i:530:p:886-895
    DOI: 10.1080/01621459.2019.1593178
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    Cited by:

    1. Elena Geminiani & Giampiero Marra & Irini Moustaki, 2021. "Single- and Multiple-Group Penalized Factor Analysis: A Trust-Region Algorithm Approach with Integrated Automatic Multiple Tuning Parameter Selection," Psychometrika, Springer;The Psychometric Society, vol. 86(1), pages 65-95, March.
    2. Petti, Danilo & Eletti, Alessia & Marra, Giampiero & Radice, Rosalba, 2022. "Copula link-based additive models for bivariate time-to-event outcomes with general censoring scheme," Computational Statistics & Data Analysis, Elsevier, vol. 175(C).
    3. Marra, Giampiero & Farcomeni, Alessio & Radice, Rosalba, 2021. "Link-based survival additive models under mixed censoring to assess risks of hospital-acquired infections," Computational Statistics & Data Analysis, Elsevier, vol. 155(C).
    4. Geminiani, Elena & Marra, Giampiero & Moustaki, Irini, 2021. "Single and multiple-group penalized factor analysis: a trust-region algorithm approach with integrated automatic multiple tuning parameter selection," LSE Research Online Documents on Economics 108873, London School of Economics and Political Science, LSE Library.

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