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Effectiveness and Cost Effectiveness of Human Papillomavirus Vaccine

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  • Fawziah Marra
  • Karine Cloutier
  • Bridgette Oteng
  • Carlo Marra
  • Gina Ogilvie

Abstract

The recent approval of human papillomavirus (HPV) vaccine means that decision makers need information beyond that available from randomized clinical trials to recommend funding for this vaccination programme. Modelling and economic studies have addressed some of those information needs. We conducted a qualitative systematic review to summarize the existing data. Review articles were obtained from an extensive literature search on studies using mathematical modelling (either a Markov or transmission dynamic model) to determine the effectiveness or cost effectiveness of an HPV vaccine compared with the current cytology-based Pap smear screening programme. A total of 21 studies (but 22 models) were included in the review after being assessed for methodological quality. All of the included studies had used a mathematical model to determine the effectiveness of an HPV vaccine, whilst 13 had also conducted a cost-effectiveness analysis. Although the studies used different model structures, baseline parameters and assumptions, all studies showed that vaccination would decrease rates of HPV infection, precancerous lesions and cervical cancer. Studies had a consistent message with respect to cost effectiveness: a female-only vaccination programme is cost effective compared with the current cytology-based Pap smear screening programme, while the cost effectiveness of a male and female vaccination programme is generally not cost effective compared with female-only vaccination. Copyright Adis Data Information BV 2009

Suggested Citation

  • Fawziah Marra & Karine Cloutier & Bridgette Oteng & Carlo Marra & Gina Ogilvie, 2009. "Effectiveness and Cost Effectiveness of Human Papillomavirus Vaccine," PharmacoEconomics, Springer, vol. 27(2), pages 127-147, February.
    • Handle: RePEc:spr:pharme:v:27:y:2009:i:2:p:127-147
    DOI: 10.2165/00019053-200927020-00004
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    Cited by:

    1. Nadia Demarteau & Thomas Breuer & Baudouin Standaert, 2012. "Selecting a Mix of Prevention Strategies against Cervical Cancer for Maximum Efficiency with an Optimization Program," PharmacoEconomics, Springer, vol. 30(4), pages 337-353, April.
    2. Nadia Demarteau & Bruno Detournay & Bertrand Tehard & Abdelkader El Hasnaoui & Baudouin Standaert, 2011. "A generally applicable cost-effectiveness model for the evaluation of vaccines against cervical cancer," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 56(2), pages 153-162, April.
    3. van Ackere, Ann & Schulz, Peter J., 2020. "Explaining vaccination decisions: A system dynamics model of the interaction between epidemiological and behavioural factors," Socio-Economic Planning Sciences, Elsevier, vol. 71(C).
    4. Hristina Lebanova & Svetoslav Stoev & Emilia Naseva & Violeta Getova & Wei Wang & Ugne Sabale & Elina Petrova, 2023. "Economic Burden of Cervical Cancer in Bulgaria," IJERPH, MDPI, vol. 20(3), pages 1-12, February.
    5. Steffen Flessa & Dominik Dietz & Elisabete Weiderpass, 2016. "Health policy support under extreme uncertainty: the case of cervical cancer in Cambodia," EURO Journal on Decision Processes, Springer;EURO - The Association of European Operational Research Societies, vol. 4(3), pages 183-218, November.

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